Abstract: Advances in the Research of Surgical Margins for Pleomorphic Adenoma of Parotid GlandChao LI1, Yiquan XU2, Jinchuan FAN1Corresponding author: Jinchuan FAN, E-mail: xuyqqing@163.com1Department of Head and Neck Surgery, Sichuan Cancer Hospital & Cancer Institute, Chengdu 610041, China2Guangxi Medical University, Nanning 530021, ChinaAbstract Pleomorphic adenoma is the most common neoplasm of the salivary glands, accounting for about 60%~70% of all pa-rotid tumors. The benign mixed tumor is composed of epithelial and myoepithelial cells arranged in various morphological patterns andsubtypes. The standard treatment for pleomorphic adenoma is surgery. After the simple procedure of tumor enucleation, the recurrencerate varies from 10% to 45%. More and more studies showed that the occasional local recurrence of benign pleomorphic adenoma (PA)was correlated with the histopathology of the tumor capsule. After enucleation, residual focal infiltration of the tumor capsule, pseudo-podia or satellite of the pleomorphic adenoma can lead to recurrence. Therefore, it is generally accepted that the standard surgical proce-dure for pleomorphic adenoma of the superficial parotid gland is superficial parotidectomy. Some authors have proposed total superfi-cial parotidectomy due to theory of multicentricity of pleomorphic adenoma. These procedures can help decrease the recurrence rate to0.3% to 4%. Some other authors have proposed extracapsular dissection or partial superficial parotidectomy, which could save the func-tion of the parotid gland and does not raise the recurrence rate. Recent advances in the research of the safe surgical margins for pleomor-phic adenoma were reviewed in this article.Keywords Pleomorphic adenoma; Parotid gland; Safe surgical margin; Molecule margin